The huge 18-wheelers in which drugs are delivered from the chain warehouse to individual stores are not temperature-controlled. If the truck leaves the chain warehouse at 8 a.m. and makes its final delivery at 6 p.m., the drugs have been sitting in a stone-cold truck for 10 hours. So mail order is not the only situation in which drugs might be at risk from extreme weather.
She was scheduled for a stool transplant, but her husband got her into a clinical trial for a drug called Dificid. After two weeks on this antibiotic, she recovered, and she has now been well for several years.
It seems to me that doctors don’t do a good job diagnosing and treating this problem. Shouldn’t doctors and dentists be more careful about prescribing clindamycin, considering the horrible effects of this infection?
Dificid (fidaxomicin) was approved in 2011 specifically for treating Clostridium difficile intestinal infections. Adverse reactions of this drug include nausea, vomiting, diarrhea, stomachache and headache. Another side effect is financial: A 10-day course of Dificid can cost more than $3,000.
An alternate treatment is fecal transplant. A recent review found that a liquid suspension of stool from a healthy donor (administered by colonoscopy, enema or nasogastric tube) is a safe and effective method for treating C. diff infections (Journal of Clinical Gastroenterology online, Jan. 16, 2014).
Asthma and infections
Reach Joe and Terry Graedon at PeoplesPharmacy.com.