April 6, 2014

Was President Harrison killed by bacteria?

William Henry Harrison, the ninth president of the United States,was our shortest-serving president, dying April 4, 1841, after just a month in office. The diagnosis was pneumonia. But the cause could have actually been exposure to bacteria from sewage.

William Henry Harrison, the ninth president of the United States, was our shortest-serving president, dying April 4, 1841, after just a month in office.

What killed him? Historians have long accepted the diagnosis of Harrison’s doctor, Thomas Miller: “Pneumonia of the lower lobe of the right lung, complicated by congestion of the liver.”

The pneumonia was thought to be a direct result of a cold the 68-year-old Harrison caught while delivering a numbingly long inaugural address (at 8,445 words, the longest in history) in wet, freezing weather without a hat, overcoat or gloves.

But a new look at the evidence through the lens of modern epidemiology makes it far more likely that the real killer lurked elsewhere – in a fetid marsh not far from the White House.

The first clue that the pneumonia diagnosis was wrong lies in Miller’s own apparent uneasiness with it.

“The disease,” he wrote, “was not viewed as a case of pure pneumonia; but as this was the most palpable affection, the term pneumonia afforded a succinct and intelligible answer to the innumerable questions as to the nature of the attack.”

Harrison – who had some medical training as a young man – summoned Miller to the White House on March 26, complaining not of a lung ailment but of anxiety and fatigue. But Miller may have overlooked a clue that was in front of his nose.

In those days, the nation’s capital had no sewer system. Until 1850, some sewage simply flowed onto public grounds a short distance from the White House, where it stagnated and formed a marsh; the White House water supply was just seven blocks downstream of a depository for “night soil,” hauled there each day at government expense.

That field of human excrement would have been a breeding ground for two deadly bacteria, Salmonella typhi and S. paratyphi, the causes of typhoid and paratyphoid fever – also known as enteric fever, for their devastating effect on the gastrointestinal system.

Harrison had a history of dyspepsia, or indigestion, which potentially heightened his risk of infection by gastrointestinal pathogens that might have found their way into the White House water supply.

Although we have no record of how he managed his dyspepsia, the standard treatment in the 1840s was carbonated alkali, which would have neutralized the gastric acid that otherwise kills harmful bacteria. In the absence of the gastric acid barrier, gastroenteritis can be caused by as few as one ten-thousandth the number of bacteria usually needed.

In 1841, there was no effective treatment for enteric fever.

Miller gave him a host of toxic medications that were then considered the standard of care – including opium, which retards the intestine’s ability to rid itself of microbial pathogens, facilitating their invasion into the bloodstream.

Enemas, which Miller repeatedly gave to Harrison, are also potentially dangerous in such patients. They can perforate ulcers produced by S. typhi and S. paratyphi in the ileum, the lower end of the small intestine, through which the bacteria would be able to escape from the intestine into the bloodstream, resulting in sepsis.

As he lay dying, Harrison had a sinking pulse and cold, blue extremities, two classic manifestations of septic shock. Given the character and course of his fatal illness, his untimely death is best explained by enteric fever. Pneumonia was a secondary diagnosis – as Harrison’s hapless doctor perhaps suspected all along.

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