Davidson (1-5, 0-2) at Drake (2-3, 1-1)
Drake Stadium, Des Moines, Iowa, 2 p.m.
The Wildcats take a five-game losing streak into Saturday’s Pioneer League game against the Bulldogs. … Drake leads the all-time series with Davidson 6-1, and has won 17 consecutive league games at home. … Despite the losses, the Wildcats have one of the league’s top offenses (419.7 yards per game). But they’re facing a Bulldogs defense that’s second in the league (331.0 ypg). Bill Kiser
Winston-Salem State (4-1, 2-0) at Johnson C. Smith (1-4, 0-2)
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Memorial Stadium, 2 p.m.
The Golden Bulls will try to snap a three-game losing streak against CIAA Southern Division leader Rams. … Winston-Salem State is second in the league in total offense (455.4 yards per game), defense (321.8 ypg) and points scored (38.2 per game), while J.C. Smith is at the bottom in offense (244.2 ypg, 7.8 ppg) and next to last in defense (441.0 ypg). B.K.
Louisville (5-1, 3-1) at Clemson (3-2, 2-1)
Memorial Stadium, Clemson, S.C., 3:30 p.m. (ESPNU)
The Tigers will host the Cardinals for the first time ever with positioning in the ACC Atlantic Division standings on the line. … Louisville has one of the nation’s top defenses, leading in yards allowed (230.0 per game), rushing yards (58.3 ypg) and interceptions (12). … Clemson freshman QB Deshaun Watson is second in the nation in passing efficiency (197.9). B.K.
Liberty (3-3) at Appalachian State (1-4, 0-2)
Kidd Brewer Stadium, Boone, 3:30 p.m.
The Mountaineers look to end a three-game losing streak when they take on the Flames of the FCS’s Big South. … Appalachian State leads the all-time series 7-2, but its last game against Liberty was in 2002. … Flames QB Josh Woodrum has thrown for 1,544 yards and 11 TDs this season. B.K.
East Carolina (4-1, 1-0) at South Florida (2-3, 1-0)
Raymond James Stadium, Tampa, Fla., 7 p.m. (ESPNU)
The 19th-ranked Pirates will go for their first win ever against the Bulls in Saturday’s nationally-televised American Athletic Conference game … USF is 4-0 all-time against East Carolina, including a 2-0 mark as former Conference USA opponents. But their last meeting was in 2006 at the PapaJohns.com Bowl. B.K.