Interstate 77 northbound at the Interstate 85 interchange was reopened shortly before 11 a.m. Wednesday, after a three-vehicle crash shut down traffic for nearly two and a half hours.
Traffic remained sluggish in areas, due to backups that at one point stretched for miles.
The crash was first reported at 7 a.m. on Interstate 77, one mile north of the Interstate 85 exit.
A tweet sent out by WBTV showed a tractor trailer truck had pinned a pickup against one of the concrete barriers along the interstate in a construction area.
Medic said two people went to the hospital with serious injuries and a third person had minor injuries, reported WBTV.
TV station WSOC tweeted out that the traffic gridlock was such that frustrated motorists were outside of their cars, talking on their cell phones and walking along the interstate.
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Officials did not say what caused the wreck, WBTV reported.