A wreck involving a fatality closed East W.T. Harris Boulevard at Old Concord Road on Saturday afternoon, emergency officials said.
Medic confirmed that one person died in the wreck, which happened shortly after 3 p.m.
Medic took two people with potentially life-threatening injuries from the wreck to Carolinas Medical Center.
At 7 p.m., a wreck was backing up traffic on Interstate 77 southbound near Nations Ford Road.
It could take until 8 p.m. to clear the wreck, highway officials said.