No. 3 CLEMSON (2-0, ACC 0-0) at No. 14 LOUISVILLE (2-0, 1-0)
Papa John’s Cardinal Stadium, Louisville, 8 p.m., WSOC-TV
Clemson’s defense had 11 sacks and 14 tackles for loss last week against Auburn. Now the Tigers will try to slow down Heisman Trophy winner Lamar Jackson, who accounted for nearly 460 yards in Louisville’s 42-36 loss at Clemson last year.
FURMAN (0-2) at N.C. STATE (1-1)
Carter-Finley Stadium, Raleigh, 12:20 p.m., WBTV
The Paladins have two last-second losses, and their defense (five sacks) will test the Wolfpack. But Furman has two freshmen on the offensive line, and that could be a big problem against the Wolfpack’s tough defensive line.
BAYLOR (0-2) at DUKE (2-0)
Wallace Wade Stadium, Durham, 12:30 p.m., Fox Sports Carolinas
Reeling from two bad losses, the visiting Bears have shaken up the lineup with a new quarterback (sophomore Zach Smith) and five new linemen. Baylor’s porous pass defense will face a huge test from Duke’s offense, which averages 50.5 points.
UTAH STATE (1-1) at WAKE FOREST (2-0)
BB&T Field, Winston-Salem, 3 p.m.
The visiting Aggies haven’t won a road game in two years. Senior quarterback Kent Myers leads a spread option attack and has passed for more than 5,000 yards in his career. ... Wake Forest’s defense created nightmares for Boston College last week, with Cameron Glenn forcing a fumble and intercepting a pass.
NORTH CAROLINA (0-2) at OLD DOMINION (2-0)
S.B. Ballard Stadium, Norfolk, 3:30 p.m.
The host Monarchs’ strength, their ground game, has been hobbled by an injury to senior running back Ray Lawry. But they face a Tar Heels defense that has big problems stopping the run, so that could be the key to this game.
KENTUCKY (2-0, SEC 0-0) at SOUTH CAROLINA (2-0, 1-0)
Williams-Brice Stadium, Columbia, 7:30 p.m., SEC Network
Kentucky’s shaky pass defense gets a test from Gamecocks quarterback Jake Bentley and receiver Deebo Samuel. The Wildcats have won three in a row against South Carolina after the Gamecocks took 13 of the previous 14.
No. 20 N.C. A&T (2-0) at CHARLOTTE (0-2)
Jerry Richardson Stadium, Charlotte, 6 p.m., WCCB-TV
Running back Tarik Cohen, the Aggies’ standout last season, is with the Chicago Bears. But 5-foot-8 junior Marquell Cartwright has stepped up, rushing for 182 yards in the first two games. Charlotte’s running game has been a trouble spot, and the Aggies are holding foes to 43.5 rushing yards.
No. 16 VIRGINIA TECH (2-0) at EAST CAROLINA (0-2)
Dowdy-Ficklen Stadium, Greenville, 3:30 p.m., CBS Sports Network
The reeling Pirates have yielded more than 1,200 yards offense, and coach Scotty Montgomery changed defensive coordinators this week. Pirates quarterback Thomas Sirk (concussion) might not play. Hokies freshman quarterback Josh Jackson has 222 yards rushing.
APPALACHIAN STATE (1-1, Sun Belt 0-0) at TEXAS STATE (1-1, 0-0)
Bobcat Stadium, San Marcos, Texas, 7 p.m.
The Mountaineers open a bid for the Sun Belt title, coming off a 54-7 rout of Savannah State. Tyler Lamb threw five touchdown passes. ...Texas State QB Damian Williams struggled in last week’s 37-3 loss at Colorado but has a quick-strike offense. ...Texas State’s coach is Charlotte native Everett Withers (West Charlotte High), an Appalachian State defensive back in the 1980s and former interim head coach at North Carolina.
COASTAL CAROLINA (1-0) at UAB (1-1)
Legion Field, Birmingham, 1 p.m.
Senior running back Osharmar Abercrombie rushed for 149 yards two weeks ago in the Chanticleers’ victory over Massachusetts. This game pits a new FBS program (Coastal Carolina) against a program that dropped football two years ago but revived it this season.
WESTERN CAROLINA (1-1) at GARDNER-WEBB (0-2)
Spangler Stadium, Boiling Springs, 6 p.m.
Gardner-Webb has scored three points this season. Catamounts quarterback Tyrie Adams passed for 427 yards last season in Western Carolina’s 44-14 rout of the Runnin’ Bulldogs.
JOHNSON C. SMITH (0-2) at S.C. STATE (0-1)
Dawson Stadium, Orangeburg, S.C., 2 p.m.
The Golden Bulls hit the road after home losses to Wingate and Virginia State. Linebacker Darius Leonard, an NFL prospect, leads a tough Bulldogs defense. The Bulldogs’ game last week against Charleston Southern was cancelled because of Hurricane Irma.
GUILFORD (2-0) at DAVIDSON (1-1)
Richardson Stadium, Davidson, 7 p.m.
Guilford’s De’Eric Bell had a 97-yard kickoff return for a touchdown last week and leads NCAA Division III in kick return yardage. Davidson is coming off a 63-17 loss at Western Carolina, but running back Wesley Dugger rushed for 117 yards.