| Date | Opponent | Location | Time |
| Nov. 14 | Presbyterian (Coaches vs. Cancer) | Durham | 6:00 |
| Nov. 15 | Fairfield (Coaches vs. Cancer) | Durham | 8:00 |
| Nov. 18 | Michigan State (Champions Classic) | Indianapolis | 7:00 |
| Nov. 21 | Temple (Coaches vs. Cancer) | Brooklyn, N.Y. | 9:30 |
| Nov. 22 | Stanford/UNLV (Coaches vs. Cancer) | Brooklyn, N.Y. | TBA |
| Nov. 26 | Furman | Durham | 5:00 |
| Nov. 30 | Army | Durham | Noon |
| Dec. 3 | Wisconsin (ACC/Big Ten Challenge) | Madison, Wis. | 9:30 |
| Dec. 15 | Elon | Durham | 7:00 |
| Dec. 18 | Connecticut | East Rutherford, N.J. | 8:00 |
| Dec. 29 | Toledo | Durham | 7:00 |
| Dec. 31 | Wofford | Durham | 3:00 |
| Jan. 3 | Boston College | Durham | 4:00 |
| Jan. 7 | Wake Forest | Winston-Salem | 9:00 |
| Jan. 11 | N.C. State | Raleigh | TBA |
| Jan. 13 | Miami | Durham | 9:00 |
| Jan. 17 | Louisville | Louisville, Ky. | Noon |
| Jan. 19 | Pitt | Durham | 7:00 |
| Jan. 25 | St. John's | New York | TBA |
| Jan. 28 | Notre Dame | South Bend, Ind. | 7:30 |
| Jan. 31 | Virginia | Charlottesville, Va. | TBA |
| Feb. 4 | Georgia Tech | Durham | 7:00 |
| Feb. 7 | Notre Dame | Durham | 1:00 |
| Feb. 9 | Florida State | Tallahassee, Fla. | 7:00 |
| Feb. 14 | Syracuse | Syracuse, N.Y. | 6:00 |
| Feb. 18 | North Carolina | Durham | 9:00 |
| Feb. 21 | Clemson | Durham | 4:00 |
| Feb. 25 | Virginia Tech | Blacksburg, Va. | 9:00 |
| Feb. 28 | Syracuse | Durham | TBA |
| March 4 | Wake Forest | Durham | 8:00 |
| March 7 | North Carolina | Chapel Hill | TBA |
| March 10-14 | ACC tournament | Greensboro | TBA |
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