No. 17 LOUISVILLE (0-0 ACC, 1-0) at NORTH CAROLINA (0-0, 0-1)
Kenan Stadium, Chapel Hill, noon ESPN
In this ACC opener, the Tar Heels must figure out a way for their offense to keep Heisman winner Lamar Jackson off the field. Louisville was far from impressive in its narrow victory over Purdue last week.
NORTHWESTERN (1-0) at DUKE (1-0)
Wallace-Wade Stadium, Durham, noon ESPNU
Linebacker Joe Giles-Harris and the Blue Devil defense will look to dominate an inexperienced Northwestern offensive line. The key could be how Duke quarterback Daniel Jones fares.
WAKE FOREST (0-0 ACC, 1-0) at BOSTON COLLEGE (0-0, 1-0)
Alumni Stadium, Chestnut Hill, Mass., 1 p.m.
The first team to seven points wins, right? As usual, these ACC foes are defensive powers, but Wake’s offense looked strong in Week 1. And Boston College’s standout center, Jon Baker, injured his knee last week and won’t play Saturday.
MARSHALL (1-0) at N.C. STATE (0-1)
Carter-Finley Stadium, Raleigh, 6 p.m.
Marshall’s offensive line struggled in last week’s 31-26 victory over Miami (Ohio), and the strong Wolfpack defense will look to dominate. Marshall’s Keion Davis returned two kickoffs for touchdowns last week.
No. 13 AUBURN (1-0) at No. 3 CLEMSON (1-0)
Memorial Stadium, Clemson, S.C., 7 p.m. ESPN
Both teams have strong defenses, and the key might be if Clemson can stop the Auburn running game. Clemson quarterback Kelly Bryant threw for 236 yards last week against Kent, but the level of opposition rises this week.
SOUTH CAROLINA (0-0 SEC, 1-0) at MISSOURI (0-0, 1-0)
Memorial Stadium, Columbia, Mo., 7 p.m. ESPN2
Let this sink in: Missouri gave up 43 points last week to an FCS team (but scored 72). Quarterback Jake Bentley and the Gamecocks scored 35 against a strong N.C. State defense. Expect a lot of scoring here in the Gamecocks’ SEC opener.
EAST CAROLINA (0-1) at WEST VIRGINIA (0-1)
Milan Puskar Stadium, Morgantown, W.Va., noon Fox Sports 2
The Pirates’ pass defense was porous in last week’s loss to James Madison. Now they must stop Charlotte-area native Will Grier and a Mountaineer team smarting from a close loss to Virginia Tech.
SAVANNAH STATE (0-0) at APPALACHIAN STATE (0-1)
Kidd-Brewer Stadium, Boone, 3:30 p.m.
Mountaineer quarterback Taylor Lamb played well in last week’s 31-10 loss to Georgia, but the Apps were hurt by penalties. They face an FCS foe that hasn’t had a winning season in 19 years.
GARDNER-WEBB (0-1) at WYOMING (0-1)
War Memorial Stadium, Laramie, Wyo., 4 p.m.
This is not an easy assignment for the Bulldogs, coming off a 45-3 loss to N.C. A&T. Their Rocky Mountain trip pits them against Wyoming quarterback Josh Allen, considered an NFL prospect. But Allen was picked off twice last week in Wyoming’s 24-3 loss to Iowa.
DAVIDSON (1-0) at WESTERN CAROLINA (0-1)
E.J. Whitmire Stadium, Cullowhee, 6 p.m.
Freshman Wesley Dugger rushed for 196 yards in Davidson’s romp over Brevard last week. The Catamounts had seven different receivers catch passes but also had three blocked field goals in their 41-18 loss two weeks ago at Hawaii.
VIRGINIA STATE (0-0 CIAA, 1-0) at JOHNSON C. SMITH (0-1)
Irwin Belk Complex, Charlotte, 4 p.m.
The visiting Spartans are coming off a victory over FCS Norfolk State last week, with Trenton Cannon rushing for 145 yards. Terrance Ervin passed for 228 yards and rushed for 57 in the Golden Bulls’ loss to Wingate.