PITTSBURGH (2-1, 1-0 ACC) at NORTH CAROLINA (0-2, 0-0)
Kenan Stadium, Chapel Hill, 12:20 p.m., WBTV
Panthers RB Qadree Allison averages 6.3 yards per carry, and he rushed for more than 100 yards against Penn State. The Tar Heels gave up more than 200 rushing yards to East Carolina two weeks ago, and stopping the run could be UNC’s key in this game.
No. 3 CLEMSON (3-0, 0-0 ACC) at GEORGIA TECH (1-2, 0-1)
Bobby Dodd Stadium, Atlanta, 3:30 p.m., WSOC
The Yellow Jackets have eight turnovers this season. That’s big trouble for a team facing a defense like Clemson’s. Georgia Tech has been hurt by injuries, but Clemson LB Kendall Joseph is out for this game, and QB Kelly Bryant is a question mark.
SOUTH CAROLINA (1-1, 0-1 SEC) at VANDERBILT (2-1, 0-0)
Vanderbilt Stadium, Nashville, 4 p.m., SEC Network
The Gamecocks were stopped by a strong Georgia defense two weeks ago and faced another rugged unit at Vanderbilt. This is the kind of game the Gamecocks must win, if they want a double-digit victory season.
No. 8 NOTRE DAME (3-0) at WAKE FOREST (2-1)
BB&T Field, Winston-Salem, noon, WSOC
Notre Dame had trouble with Ball State’s fast-tempo offense last week, and the Deacons like to keep it moving. Who starts at QB for Wake – freshman Sam Hartman of Davidson Day, who’s played well in the first three game; or Kendall Hinton, who is returning from suspension?
N.C. CENTRAL (1-1) at DUKE (3-0)
Wallace Wade Stadium, Durham, 3:30 p.m.
The Blue Devils’ final nonconference game is a chance for new QB Quenton Harris to become more familiar with his role. The Bull City Gridiron Classic is expected to draw a full house.
N.C. STATE (2-0) at MARSHALL (2-0)
Edwards Stadium, Huntington, W.Va., 7 p.m., CBS Sports Network
Marshall WR Tyre Brady had 248 receiving yards in his team’s 37-20 loss last season at N.C. State. The Marshall pass defense has been shaky in both its games, so look for the Wolfpack, behind QB Ryan Finley, to air it out.
EAST CAROLINA (1-1, 0-0 American) at SOUTH FLORIDA (3-0, 0-0)
Raymond James Stadium, Tampa, 8 p.m. ESPN News
South Florida QB Blake Barnett threw for more than 400 yards last week against Illinois. So to stay in the game, the Pirates will need the offense that scored 41 points against North Carolina to show up again this week.
CHARLOTTE (2-1) at MASSACHUSETTS (1-3)
McGuirk Alumni Stadium, Amherst, Mass., 3:30 p.m., WCCB
The 49ers aren’t sure which of three Massachusetts QB candidates they’ll face. The host Minutemen have lost three straight and are having trouble stopping the run. Charlotte RB Benny LeMay will look to take advantage of that situation.
GARDNER-WEBB (1-2) at APPALACHIAN STATE (1-1)
Kidd Brewer Stadium, Boone, 3:30 p.m.
App State’s defense is 11th nationally against the pass, which happens to be the shaky part of the Runnin’ Bulldogs’ offense. The Mountaineers figure to have a big advantage in speed and could break some big plays.
COASTAL CAROLINA (2-1, 0-0 Sun Belt) at LOUISIANA (1-1, 0-0)
Cajun Field, Lafayette, La., 7 p.m.
The Chanticleers made national news this week, being displaced by Hurricane Florence to Jacksonville (Fla.). QB Kilton Anderson will try to take advantage of a Louisiana defense allowing 240 rushing yards a game.
DAVIDSON (3-0, 0-0 Pioneer) at DAYTON (1-2, 0-0)
Welcome Field, Dayton, Ohio, 1 p.m.
Davidson opens conference play with its first road game of the season, coming off the surreal 91-61 win last week against Guilford. Wildcats RB Wesley Dugger and his Dayton RB counterpart, Tucker Yinger, each are averaging more than 120 rushing yards a game.
VIRGINIA STATE (0-2, 0-0 CIAA) at JOHNSON C. SMITH (0-2, 0-0)
Irwin Belk Stadium, Charlotte, 6 p.m.
The Golden Bulls, who are surrendering an average of 400 yards a game, must stop Virginia State QB Cordelral Cook, who is rushing for more than 100 yards and completing more than 50 percent of his passes.