Region Gameday

South Carolina (2-2, 0-2 SEC) at Missouri (3-1, 0-1)

Memorial Stadium, Columbia, Mo., Noon, SEC Network

The Gamecocks have lost their past two SEC games, but have won two of their past three meetings against the Tigers. ... Missouri has won the SEC Eastern Division title the past two years, but lost its league opener to Kentucky last week.

Valparaiso (0-3, 0-1 Pioneer) at Davidson (0-3, 0-1)

Richardson Stadium, Davidson, 1 p.m.

The Wildcats have two long losing streaks on the line Saturday – a 14-game regular-season skid, and an 18-game conference streak. … Davidson leads the all-time series 7-2, and is 3-0 at home against the Crusaders.

Carson-Newman (3-1, 1-1 SAC) at Lenoir-Rhyne (3-1, 1-0)

Moretz Stadium, Hickory, 2 p.m.

The Bears face the Eagles in their home opener. … Carson-Newman leads the all-time series 43-14, but Lenoir-Rhyne has won five of the past seven games. … The Bears have won 21 straight league games.

Bowie State (3-1, 1-0 CIAA) at Johnson C. Smith (1-3, 0-1)

Irwin Belk Complex, Noon

The Golden Bulls host the Bulldogs in their first CIAA game at home. … J.C. Smith holds a slim 12-11 edge in the all-time series, but Bowie State has won six of the past seven games.

Florida State (3-0, 1-0 ACC) at Wake Forest (2-2, 0-1)

BB&T Field, Winston-Salem, 3:30 p.m., ESPN

The Deacons close out a two-game homestand against the ninth-ranked Seminoles, the defending ACC champions. … Florida State leads the all-time series 26-6-1, and has won three straight and five of the past six games.

Wyoming (0-4) at Appalachian State (2-1)

Kidd Brewer Stadium, Boone, 3:30 p.m.

The Mountaineers wrap up their nonconference schedule against the Cowboys. … The teams have played once before, with Wyoming winning 53-7 in 2004. … Appalachian State has outscored its opponents 98-0 in its two wins.

East Carolina (2-2, 0-1 AAC) at Southern Methodist (1-3, 0-0)

Gerald J. Ford Stadium, Dallas, 4 p.m., ESPNNews

The Pirates resume conference play this week against the Mustangs. … East Carolina leads the all-time series 3-2, including last year’s 45-24 win, its first in the American Athletic Conference. … SMU has lost two straight.

Notre Dame (4-0) at Clemson (3-0, 1-0 ACC)

Memorial Stadium, Clemson, S.C., 8 p.m., ABC

The 11th-ranked Tigers take on the No. 6 Fighting Irish for the first time in 36 years. … The teams have played twice, with the series even at 1-1. Clemson won in 1979, while Notre Dame won 21-17 in 1977 behind quarterback Joe Montana’s two rushing touchdowns.

Bill Kiser

Louisville (1-3) at N.C. State (4-0)

Carter-Finley Stadium, Raleigh, 12:30 p.m., WBTV

N.C. State has run all over its first four opponents and had a season-best 330 rushing yards in last week’s 63-13 slaughter of South Alabama. Junior running back Matt Dayes leads the country with nine rushing touchdowns and has averaged 113.5 yards per game. Louisville has a bigger and deeper defensive front than any team N.C. State has faced this season.

Joe Giglio

North Carolina (3-1) at Georgia Tech (2-2)

Bobby Dodd Stadium, Atlanta, 3:30 p.m., ESPNU

There have been some wild UNC-Georgia Tech games the past few years and the Tar Heels are seeking something of a wild result: the end of an eight-game losing streak in Atlanta. A win would also be a rare victory in a conference opener for UNC, which has won just one ACC opener since 2001.

Andrew Carter

Boston College (3-1) at Duke (3-1)

Wallace Wade Stadium, Durham, 3:30 p.m., FSCR

The Eagles’ defense ranks first nationally in total defense and surrenders 7.8 points per game, the second-lowest figure nationwide. Boston College is down without its starting quarterback (broken leg) and running back (broken foot), so offense will be hard to come by for the Eagles.

Laura Keeley